rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
In summary, magnolol could effectively lower the plasma triglyceride levels in APOA5 c.553G>T variant carrier mice and facilitate the triglyceride metabolism in postprandial hypertriglyceridemia.
|
29425239 |
2018 |
rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in hiv-infected individuals in Taiwan.
|
19187029 |
2009 |
rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).
|
25127531 |
2014 |
rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
To measure the correlation between the c.553G>T polymorphism and HTG susceptibility, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
|
27813673 |
2016 |
rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
Only APOA5 c.553 G > T (rs2075291), resulting in the amino acid mutation Gly185Cys, co-segregated well with hypertriglyceridemia in terms of autosomal recessive inheritance (homozygote TT: mean triglyceride level: 1,071 mg/dL vs non TT (GT and GG): mean triglyceride level: 118 mg/dL; p < 0.001) in the index family.
|
25843152 |
2015 |
rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest the possible use of c.553G>T polymorphisms in APOA5 as prognostic indicators for hypertriglyceridemia susceptibility in Chinese.
|
12915450 |
2003 |
rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
The -1131T>C and c.553G>T polymorphisms were associated with hypertriglyceridemia in the study population, but only the -1131T>C polymorphism directly affected apoA5 concentrations.
|
29211729 |
2017 |
rs2075291
|
ZPR1;APOA5
|
Hypertriglyceridemia
|
|
0.080 |
GeneticVariation |
BEFREE |
The -1131T>C and c.553G>T (G185C) polymorphisms correlated with HTG in this Japanese population, but neither polymorphism directly affected ApoA5 expression.
|
17457003 |
2007 |